SARS-CoV-2/COVID-19 Reagents

The TCF is producing reagents to study human and mouse T cell responses to SARS-CoV-2. These reagents are based on published work* as well as communication with other labs and should be available as monomers or tetramers labeled with our usual selection of fluorochromes. The epitopes are known to bind the MHC alleles we supply them with, but not all of them have been validated in a SARS-CoV-2 immune response.

These materials can be requested using the premade request forms below. You can use our standard class I and class II forms for custom SARS-CoV-2 reagents not listed here. Additional reagents may be added to or removed from the list depending on demand and validation. At this time, we can only supply 1 unit of quantity per reagent unless very strong justification for needing more can be supplied.

*PMIDs 32183941,33521695,33326767,32979941,32999467,33052343,33128877,33184509,33024971,32887977,32913053,33441437

 

Class I Premade SARS-CoV-2

Allele Description Peptide Sequence Order Options Info
H-2D(b) SARS-CoV-2 N 219-227 LALLLLDRL
*
H-2K(b) SARS-CoV-2 S 539-546 VNFNFNGL
*
HLA-A*02:01 SARS-CoV-2 S 958-996 ALNTLVKQL
HLA-A*02:01 SARS-CoV-2 N 138-146 ALNTPKDHI
HLA-A*02:01 SARS-CoV-2 S 1220-1228 FIAGLIAIV
HLA-A*02:01 SARS-CoV-2 N 315-324 GMSRIGMEV
HLA-A*02:01 SARS-CoV-2 N 350-358 ILLNKHIDA
HLA-A*02:01 SARS-CoV-2 S 996-1004 LITGRLQSL
HLA-A*02:01 SARS-CoV-2 N 222-230 LLLDRLNQL
HLA-A*02:01 SARS-CoV-2 N 159-167 LQLPQGTTL
HLA-A*02:01 SARS-CoV-2 S 1192-1200 NLNESLIDL
HLA-A*02:01 SARS-CoV-2 S 1185-1193 RLNEVAKNL
HLA-A*02:01 SARS-CoV-2 S 1000-1008 RLQSLQTYV
HLA-A*02:01 SARS-CoV-2 M 61-70 TLACFVLAAV
HLA-A*02:01 SARS-CoV-2 S 976-984 VLNDILSRL

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Class II Premade SARS-CoV-2

Allele Description Peptide Sequence Order Options Info
DRB1*01:01 SARS-CoV-2 S 873-888 GAALQIPFAMQMAYRF
DRB1*04:01 SARS-CoV-2 S 461-475 LKPFERDISTEIYQA
DRB1*04:01 SARS-CoV-2 S 939-955 QALNTLVKQLSSNFGAI
DRB1*04:01 SARS-CoV-2 S 993-1010 QLIRAAEIRASANLAATK