Product Type
Ligand
Description
OCH, an a-galactosylceramide analogue with a truncated side chain, stimulates Th2-biased cytokine production in natural killer T cells. Through a collaboration with Dr. Paul Savage at Brigham Young University, the NIH Tetramer Facility is providing mouse and human CD1d monomers and tetramers loaded with OCH.

Purified OCH ligand may also be obtained for stimulation of NK T cells in vitro or for in vivo animal studies. (The material may not be used in humans.) OCH is dissolved in a Tween/sucrose/histidine buffer, sterile-filtered, placed in autoclaved vials, and lyophilized. The resulting powder can be reconstituted in water at a final concentration of 0.2 mg/mL.
Ligand
OCH

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Premade Ligand

Requesters will receive 1 mg of lyophilized ligand per ordered item.

The Tetramer Resource Committee (TRC) meets approximately every other Friday to review tetramer requests. Requests must be received before 12 noon EST three days before a scheduled TRC meeting in order to be considered. View TRC Schedule

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Ligand Order Options
OCH
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Disclaimer: Please note that the reagents listed on this page have been produced by the NIH Tetramer Facility with strict quality control (including gene sequencing, affinity purification, SDS PAGE analysis, and verification of biotinylation by immunoprecipitation), but many have not been confirmed to stain or activate specific T cells.