SZ Ben-Sasson, A Hogg, J Hu-Li, P Wingfield, X Chen, M Crank, S Caucheteux, M Ratner-Hurevich, JA Berzofsky, R Nir-Paz, WE Paul. (2013). " IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells. " J Exp Med. 210, 491-502. PMID: 23460726 DOI: 10.1084/jem.20122006
Here, we show that interleukin-1 (IL-1) enhances antigen-driven CD8 T cell responses. When administered to recipients of OT-I T cell receptor transgenic CD8 T cells specific for an ovalbumin (OVA) peptide, IL-1 results in an increase in the numbers of wild-type but not IL1R1 OT-I cells, particularly in spleen, liver, and lung, upon immunization with OVA and lipopolysaccharide. IL-1 administration also results in an enhancement in the frequency of antigen-specific cells that are granzyme B, have cytotoxic activity, and/ or produce interferon γ (IFN-γ). Cells primed in the presence of IL-1 display enhanced expression of granzyme B and increased capacity to produce IFN-γ when rechallenged 2 mo after priming. In three in vivo models, IL-1 enhances the protective value of weak immunogens. Thus, IL-1 has a marked enhancing effect on antigen-specific CD8 T cell expansion, differentiation, migration to the periphery, and memory