Self-complementary AAVs Induce More Potent Transgene Product-specific Immune Responses Compared to a Single-stranded Genome. - 1

T Wu, K Töpfer, SW Lin, H Li, A Bian, XY Zhou, KA High, HC Ertl. (2011). " Self-complementary AAVs Induce More Potent Transgene Product-specific Immune Responses Compared to a Single-stranded Genome. " Mol Ther. 20, 572-9. PMID: 22186792 DOI: 10.1038/mt.2011.280

Using a mouse model we show that self-complementary (sc) adeno-associated virus (AAV) vectors pseudotyped with capsids of serotypes 2, 7 or 8 induce more potent transgene product-specific CD8(+) T cell and antibody responses compared to corresponding single-stranded (ss)AAV vectors. These data suggest that the higher and more rapidly appearing amounts of transgene product achieved with scAAV vectors may increase detrimental immune responses in gene transfer recipients

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K(d)/HIV.gag.p24.AMQMLKETI