NIH Tetramer Core Facility

The NIH Tetramer Core Facility provides MHC Class I and Class II tetramer reagents to the research community worldwide.

The NIH Tetramer Facility is supported by contract HHSN272201300006C from the National Institute of Allergy and Infectious Diseases, a component of the National Institutes of Health in the Department of Health and Human Services.

Our Facility

Purpose   The NIH Tetramer Core Facility (TCF) at Emory University was established in 1999 for the production and distribution to the research community of major histocompatibility complex (MHC) tetramers and related reagents for the detection of T cell responses to viruses, bacteria, parasites, tumors, auto-antigens, and other model antigens. The TCF is funded by contract HHSN272201300006C via the National Institute of Allergy and Infectious Diseases. Reagents are provided to qualified investigators at no cost, except for cases where the investigator is asked to provide the TCF with peptide or other appropriate ligands.

Why Tetramers?

T cells play essential effector and regulatory roles in adaptive immune responses to viruses, bacteria, parasites, tumors, transplanted tissues, allergens and even to self antigens. Antigen-specific T cell responses can be detected by functional assays—e.g. lymphoproliferation assays, cytotoxic T cell assays using chromium release, and cytokine production assays such as the ELISpot assay and intracellular cytokine staining—or by antigen-binding methods.

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