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If the desired MHC allele is not currently available
from the NIH Tetramer Core Facility,
the requester must supply the appropriate clone. The
plasmid will not be distributed, but the cDNA becomes
property of the NIH Tetramer Facility. The requester
must agree to allow the NIH Tetramer Facility to retain
the plasmid, subclone the cDNA into the appropriate expression
vector, and produce the allele for future distribution
of tetramer reagents.
Other special requests (such as an alternative species
of beta-2 microglobulin) can be handled in the same manner.
To suggest an allele for production, email Amy
Stout, Project Manager for the NIH Tetramer Facility.
Please note that the NIH Tetramer Facility cannot provide
certain Class I MHC tetramers that are commercially available
from Beckman Coulter Immunomics Operations (BCI) except
to NIH researchers. A list of these excluded tetramers can be found here.
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